Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Detection of HCC can be difficult, as most of the patients who develop this tumor have no symptoms other than those related to their longstanding liver disease. There is an urgent need to understand the molecular mechanisms that are responsible for the development of this disease so that appropriate therapie...
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Insights into the three-dimensional (3D) structure of the enzyme, Methionine S-adenosyltransferase (MAT). can throw light on its role in humans and help in evolving se lectivity attributes of inhibitors targeted at bacterial MAT. We report here a 30model of human MAT, using the X-ray structure of MAT from the rat as a template, by comparative protein modeling principles. The resulting model has...
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It has been shown that changes of intracellular levels of S-adenosylmethionine (SAM) are related to the well beings of cells and organisms. The fluctuation of SAM level is cause by imbalance between SAM synthesis and metabolic pathways (methylation, transsulfuration and aminiopropylation) or degradation. S-adenosylmethionine biosynthesis is strictly and solely dependent on the activity of Methi...
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Methionine adenosyltransferase (MAT) catalyzes the formation of V adenos.vlmethionine (SAM), the principal methyl donor, and is essential to normal cell function. The two forms of MAT, liver specific and non-liver specific, are products of two genes, MATI A and MAT2A, respectively. We have reported a switch from MATI A to MAT2A gene expression in human liver cancer cells. In the current work, w...
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In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. In liver, MAT1A expression is associated with high AdoMet levels and a differentiated phenotype, whereas MAT2A expression is associated with lower AdoMet levels and a dedifferentiated phenotype. In the current study, we examined regulati...
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ژورنال
عنوان ژورنال: Cancers
سال: 2011
ISSN: 2072-6694
DOI: 10.3390/cancers3021480